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Y-27632 Dihydrochloride CAS #129830-38-2 is an ATP-competitive inhibitor of ROCKs including pl60ROCK (Ki = 140nM) and ROCK-11 (IC50 = 800 nM). At a concentration of 10µM, Y-27632 blocks apoptosis of dissociated cultured human embryonic stem cells, increasing cloning efficiency by 25% and sustaining survival up to 30 passages. Manufactured to meet an ultra-pure standard greater than 99%. Rose welcomes inquiries about the availability of much larger quantities or chemicals that are not yet part of its regular catalog.
| Product | Y-27632 (2HCL) |
|---|---|
| CAS Number | 129830-38-2 |
| Catalog Number | BT-2017-000 |
| Molecular Formula | C14H21N3O.2HCl |
| Molecular Weight | 320.25 |
| Appearance | Crystalline Powder, Off-White |
| Purity | ≥ 99+ (HLPC) |
| Solubility | Completely Soluble in MeOH & H2O, DMSO and Ethanol |
| NMR Spectrum | Conforms to Structure |
| Storage | Stable at -20ºC for 3 years |
| Toxicity | Unknown, Avoid Exposure |
| Synonyms | trans-4-[(1R)-1-Aminoethyl]-N-4-pyridinylcyclohexanecarboxamide di-hydrochloride, ROCK inhibitor Y-27632 |
